Multigeneration reproductive toxicity assessment of 60-Hz magnetic fields using a continuous breeding protocol in rats

Teratology ◽  
1999 ◽  
Vol 59 (3) ◽  
pp. 156-162 ◽  
Author(s):  
Bernadette M. Ryan ◽  
Richard R. Symanski ◽  
Lisa E. Pomeranz ◽  
Tim R. Johnson ◽  
James R. Gauger ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Reproductive Toxicity ◽  
Toxicity Assessment

Effect of oral administration of carbofuran on male reproductive system of rat

1995 ◽  
Vol 14 (11) ◽  
pp. 889-894 ◽  
Author(s):  
N. Pant ◽  
AK Prasad ◽  
SC Srivastava ◽  
R. Shankar ◽  
SP Srivastava
Keyword(s):  
Body Weight ◽  
Sperm Count ◽  
Reproductive Toxicity ◽  
Giant Cells ◽  
Toxicity Assessment ◽  
Male Rats ◽  
Ventral Prostate ◽  
Seminiferous Tubules ◽  
Effect Level ◽  
Dose Dependent Decrease

1 Carbofuran was administered orally to adult male rats at dose levels of 0.1, 0.2, 0.4 or 0.8 mg kg -1 body weight, 5 d wk-1 for 60 days. A dose dependent decrease was observed in body weight of rats treated with 0.2-0.8 mg carbofuran kg -1 body weight 2 A significant decrease in the weight of epididymides, seminal vesicles, ventral prostate and coagulating glands was observed at various test doses of carbofuran except at the lowest dose. 3 Decreased sperm motility, reduced epididymal sperm count along with increased morphological abnormali ties in head, neck and tail regions of spermatozoa were observed in rats exposed to 0.2, 0.4, or 0.8 mg carbo furan kg-1 body weight. 4 In addition, significant alterations were observed in the activities of marker testicular enzymes viz. sorbitol dehydrogenase (SDH), glucose-6-P-dehydrogenase (G6PDH) (decreased), lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (γ-GT) (increased) depending on dose. 5 Histologically, the results indicated the toxicity of carbo furan on testes depending on dose. The changes pre dominantly consisted of moderate oedema, congestion, damage to Sertoli cells and germ cells, along with the accumulation of cellular debris and presence of giant cells in the lumen of a few seminiferous tubules which showed disturbed spermatogenesis with the higher doses of carbofuran. 6 These observations determined a no effect level dose of 0.1 mg kg-1 body weight of carbofuran on the biochemi cal and morphological indices studied for male repro ductive toxicity assessment in the rat model. The results of the present study provide first hand information on the reproductive toxicity of carbofuran in male rats.

In vivo and in vitro Reproductive Toxicity Assessment of Ampicillin and Cloxacillin in Mammalian Models

2005 ◽  
Vol 2 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Y. Raji . ◽  
F.O. Awobajo . ◽  
Olufadekemi . ◽  
T. Kunle-Alabi . ◽  
M.A. Gbadegesin . ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Assessment

Ovarian cycle and embryonic development in Gammarus fossarum: Application for reproductive toxicity assessment

2010 ◽  
Vol 29 (10) ◽  
pp. 2249-2259 ◽  
Author(s):  
Olivier Geffard ◽  
Benoit Xuereb ◽  
Arnaud Chaumot ◽  
Alain Geffard ◽  
Sylvie Biagianti ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Reproductive Toxicity ◽  
Toxicity Assessment ◽  
Ovarian Cycle ◽  
Gammarus Fossarum

Reproductive toxicity assessment of chronic dietary exposure to soy isoflavones in male rats

2004 ◽  
Vol 18 (4) ◽  
pp. 605-611 ◽  
Author(s):  
Ali S Faqi ◽  
William D Johnson ◽  
Robert L Morrissey ◽  
David L McCormick
Keyword(s):  
Reproductive Toxicity ◽  
Dietary Exposure ◽  
Toxicity Assessment ◽  
Soy Isoflavones ◽  
Male Rats

Reproductive toxicity assessment of Senecio scandens extract in kunming mice

2019 ◽  
Author(s):  
Lartey Kwame Ayisi ◽  
Nie Fang-Hong ◽  
Yu Zeng-Jie ◽  
Lin Hong-Ying ◽  
Yang Fan ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Assessment Method ◽  
Toxicity Assessment ◽  
Low Doses ◽  
Female Mice ◽  
Three Phase ◽  
Sperm Abnormality ◽  
High Doses ◽  
Dose Response Effect ◽  
Toxicity Effects

This study assessed the effects of Senecio scandens Buch. Ham.extract on reproductive spectrum in female mice using a three phase reproductive assessment method. Sperm abnormality rate was used to evaluate effect on genetic reproductive toxicity. Senecio scandens extract was relatively non-toxic at low doses in all phases of reproduction in female mice. However, it showed a dose-response effect on sperm abnormality rate, and at high doses has the potential to induce genetic reproductive toxicity in male mice. It is suggested that the well-understood pharmacological benefits of S. scandens extract as an herbal medicine far outweigh the minimal reproductive toxicity effects observed in this study.

scholarly journals Endopleura uchi (Huber) Cuatrec.: A medicinal plant for gynecological treatments – A reproductive toxicity assessment in zebrafish (Danio rerio)

2020 ◽  
Vol 250 ◽  
pp. 112457 ◽  
Author(s):  
Beatriz Martins de Sá Hyacienth ◽  
Brenda Lorena Sánchez-Ortiz ◽  
Karyny Roberta Tavares Picanço ◽  
Arlindo César Matias Pereira ◽  
Danilo Cabral de Sá Hyacienth ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Danio Rerio ◽  
Reproductive Toxicity ◽  
Toxicity Assessment
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